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It is freely soluble in methanol; soluble in ethanol; slightly soluble in acetone, water, and chloroform; and insoluble in ether.
Clomi PHENE citrate is an orally administered, nonsteroidal, ovulatory stimulant designated chemically as 2-[p-(2-chloro-1,2-diphenylvinyl) phenoxy] triethylamine citrate (1:1).
It has a molecular formula of C Clomi PHENE citrate is a white to pale yellow, essentially odorless, crystalline powder.
This initiates steroidogenesis and folliculogenesis, resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol.
Following ovulation, plasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle.
Clomi PHENE citrate is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix.
It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracellular estrogen receptors.Each white scored tablet contains 50 mg clomi PHENE citrate USP.The tablet also contains the following inactive ingredients: lactose, microcrystalline cellulose, starch, colloidal silicon dioxide, magnesium stearate and sodium starch glycolate.Available data suggest that both the estrogenic and antiestrogenic properties of clomi PHENE may participate in the initiation of ovulation.Clomi PHENE citrate is a drug of considerable pharmacologic potency.With careful selection and proper management of the patient, clomi PHENE citrate has been demonstrated to be a useful therapy for the anovulatory patient desiring pregnancy.